What it is
Caduceus adapts state-space modelling to genomics with bidirectionality and reverse-complement equivariance.
Evidence trail
BioAtlas keeps the path from source to decision visible. A connection records provenance; it does not imply that evidence is sufficient for every context.
Model passport
How Caduceus represents biology
Category is navigation. These fields describe the model-specific computational transformation and deliberately override broad category defaults.
Biological scale
Modalities & tasks
Registry, claims and frontier intelligence
Version history not yet curated
1 version record · release year not yet normalized. Model-family identity remains separate from capability and access changes.
Explore version lineage →1 normalized claim
Genomic sequence modelling · Long-range genomic benchmarks
Open claim intelligence →0 connected frontiers
No frontier-research record currently connects to this model.
Inspect research horizon →Inputs and outputs
Inputs
Long DNA sequenceOutputs
DNA embeddingsTask predictionsScientific and technical profile
Scientific principles
Technology
Scientific lineage
These are transparent concept matches—not claims that one scientist alone caused this model. Each connection is based on the model’s recorded domain, scientific principles, technical terms or an explicit lineage link.
DNA as the hereditary transforming principle
Oswald Avery, Colin MacLeod & Maclyn McCartyGenomics, variant interpretation, gene therapy and sequence foundation models depend on DNA being the durable molecular carrier of biological information.
The DNA double helix and complementary base pairing
James Watson & Francis CrickSequence analysis, variant prediction, genome design and nucleic-acid therapeutics all rest on this structural logic.
X-ray evidence for the helical structure of DNA
Rosalind Franklin & Raymond GoslingStructural genomics and sequence-to-structure reasoning began with experimentally grounded molecular geometry.
Reading the sequences of proteins and DNA
Frederick SangerBiological foundation models exist because proteins and genomes became readable, comparable and computable at scale.
The central dogma and directional information transfer
Francis CrickMulti-omic models and sequence foundation models connect genotype, transcript and protein through this information-flow framework.
Information, entropy and communication
Claude E. ShannonSequence modelling, cross-entropy training, language models, mutual information and representation learning all use Shannon’s framework.
Evaluation evidence
Task-specific evidence only; not comparable as a universal leaderboard score.
Long-range genomic benchmarks
Version history not yet curated · Split details not yet normalizedA structured benchmark claim is recorded; consult the linked source for numeric values and protocol details.
Claim caveats
- Protocol, split and implementation details must match before comparing this claim with another result.
Known limitations
- Performance depends on the evaluation dataset and operating conditions.
- Task-specific benchmark results should not be compared across unlike domains.
- Outputs require task-specific scientific and experimental validation.
Milestones
Explicitly encodes a fundamental symmetry of DNA.