AlphaFold 2 entered the model lineage

Why this model matters

AlphaFold predicts a protein's 3D structure directly from its amino-acid sequence with near-experimental accuracy. AlphaFold 2 (2020) triggered a revolution at CASP14; AlphaFold 3 (2024, with Isomorphic Labs) extended prediction to proteins bound to ligands, DNA, RNA and ions — the interactions that matter for drugs. Hassabis and Jumper shared the 2024 Nobel Prize in Chemistry with David Baker.

Current evidence boundary

• Performance depends on the evaluation dataset and operating conditions.
• Task-specific benchmark results should not be compared across unlike domains.
• Outputs require task-specific scientific and experimental validation.