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Model update · 2022 · peer-reviewed

OpenFold (AF2 reproduction) entered the model lineage

Made AlphaFold-style training and research reproducible in an open PyTorch implementation.

ModelOpenFold
OrganizationOpenFold Consortium / Columbia
Year2022
Event typeversion-release
Evidence sourcepeer-reviewed
Editorial statuscurated

Why this model matters

OpenFold is a from-scratch, trainable PyTorch reimplementation of AlphaFold 2 with open weights and training data (OpenProteinSet). It let the whole community fine-tune and study folding models rather than only run inference, and seeded a nonprofit consortium for open biomolecular AI.

Current evidence boundary

  • Performance depends on the evaluation dataset and operating conditions.
  • A structured benchmark claim has not yet been extracted for this record.
  • Outputs require task-specific scientific and experimental validation.